The 2nd Summer Institute in Statistics for Big Data (SISBID 2016) will be held at the University of Washington in Seattle, Washington during July 11-29, 2016. The Institute consists of a series of two-and-a-half day workshops (modules) designed to introduce biologists, quantitative scientists, and statisticians to modern statistical techniques for the analysis of Biological Big Data. The format will involve formal lectures, computing labs, and hands-on case studies. The instructors are world-class faculty with expertise in all aspects of Biological Big Data. Participants are encouraged to enroll in multiple modules.